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1

β2-amino acids—syntheses, occurrence in natural products, and components of β-peptides1,2

Gérald Lelais, Dieter Seebach

Journal:

Year:

2004

Language:

english

File:

PDF, 2.02 MB

english, 2004

2

Mixed β2/β3-Hexapeptides and β2/β3-Nonapeptides Folding to (P)-Helices with Alternating Twelve- and Ten-Membered Hydrogen-Bonded Rings

Magnus Rueping, Jürg V. Schreiber, Gérald Lelais, Bernhard Jaun, Dieter Seebach

Journal:

Helvetica Chimica Acta

Year:

2002

Language:

english

File:

PDF, 373 KB

english, 2002

3

Mixed β2/β3-Hexapeptides and β2/β3-Nonapeptides Folding to (P)-Helices with Alternating Twelve- and Ten-Membered Hydrogen-Bonded Rings.

Magnus Rueping, Juerg V. Schreiber, Gerald Lelais, Bernhard Jaun, Dieter Seebach

Journal:

Year:

2003

File:

PDF, 62 KB

2003

4

β2-Amino Acids: Syntheses, Occurrence in Natural Products, and Components of β-Peptides

Gerald Lelais, Dieter Seebach

Journal:

Year:

2004

File:

PDF, 11 KB

2004

5

Preparation of Protected β2- and β3-Homocysteine, β2- and β3-Homohistidine, and β2-Homoserine for Solid-Phase Syntheses.

Gerald Lelais, Peter Micuch, Delphine Josien-Lefebvre, Francesco Rossi, Dieter Seebach

Journal:

Year:

2005

File:

PDF, 16 KB

2005

6

Enantioselective Preparation of 2-Aminomethyl Carboxylic Acid Derivatives: Solving the β2-Amino Acid Problem with the Chiral Auxiliary 4-Isopropyl-5,5-diphenyloxazolidin-2-one (DIOZ). Preliminary Communication

Dieter Seebach, Laurent Schaeffer, François Gessier, Pascal Bindschädler, Corinna Jäger, Delphine Josien, Sascha Kopp, Gérald Lelais, Yogesh R. Mahajan, Peter Micuch, Radovan Sebesta, Bernd W. Schweiz

Journal:

Helvetica Chimica Acta

Year:

2003

Language:

english

File:

PDF, 296 KB

english, 2003

7

Zn2+-Complexation by a β-Peptidic Helix and Hairpin Containing β3hCys and β3hHis Building Blocks: Evidence from CD Measurements. Preliminary Communication

Francesco Rossi, Gérald Lelais, Dieter Seebach

Journal:

Helvetica Chimica Acta

Year:

2003

Language:

english

File:

PDF, 185 KB

english, 2003

8

Synthesis, CD Spectra, and Enzymatic Stability of β2-Oligoazapeptides Prepared from (S)-2-Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and Leu

Gérald Lelais, Dieter Seebach

Journal:

Helvetica Chimica Acta

Year:

2003

Language:

english

File:

PDF, 305 KB

english, 2003

9

Enantioselective Preparation of β2-Amino Acids with Aspartate, Glutamate, Asparagine, and Glutamine Side Chains

Gérald Lelais, Marino A. Campo, Sascha Kopp, Dieter Seebach

Journal:

Helvetica Chimica Acta

Year:

2004

Language:

english

File:

PDF, 304 KB

english, 2004

10

Preparation of Protected β2- and β3-Homocysteine, β2- and β3-Homohistidine, and β2-Homoserine for Solid-Phase Syntheses

Gérald Lelais, Peter Micuch, Delphine Josien-Lefebvre, Francesco Rossi, Dieter Seebach

Journal:

Helvetica Chimica Acta

Year:

2004

Language:

english

File:

PDF, 428 KB

english, 2004

11

β-Peptidic Secondary Structures Fortified and Enforced by Zn2+ Complexation – On the Way to β-Peptidic Zinc Fingers?

Gérald Lelais, Dieter Seebach, Bernhard Jaun, Raveendra I. Mathad, Oliver Flögel, Francesco Rossi, Marino Campo, Arno Wortmann

Journal:

Helvetica Chimica Acta

Year:

2006

Language:

english

File:

PDF, 2.05 MB

english, 2006

12

Electrophilic S-Trifluoromethylation of Cysteine Side Chains in α- and β-Peptides: Isolation of Trifluoro-methylated Sandostatin® (Octreotide) Derivatives

Stefania Capone, Iris Kieltsch, Oliver Flögel, Gerald Lelais, Antonio Togni, Dieter Seebach

Journal:

Helvetica Chimica Acta

Year:

2008

Language:

english

File:

PDF, 575 KB

english, 2008

13

Determination of zinc to beta-peptide binding constants with electrospray ionization mass spectrometry

Arno Wortmann, Francesco Rossi, Gerald Lelais, Renato Zenobi

Journal:

Journal of Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 173 KB

english, 2005

14

Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists

Azimioara, Mihai, Alper, Phil, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Lelais, Gerald, Mecom, John, McNeill, Matthew, Michellys, Pierre-Yves, Wang, Zhiliang, Reding, Esther, Paliotti, Mich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 851 KB

english, 2014

15

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Jia, Yong, Yun, Cai-Hong, Park, Eunyoung, Ercan, Dalia, Manuia, Mari, Juarez, Jose, Xu, Chunxiao, Rhee, Kevin, Chen, Ting, Zhang, Haikuo, Palakurthi, Sangeetha, Jang, Jaebong, Lelais, Gerald, DiDonato

Journal:

Year:

2016

Language:

english

File:

PDF, 3.63 MB

english, 2016

16

Discovery of ( R , E )- N -(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1 H -benzo[ d ]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

Lelais, Gérald, Epple, Robert, Marsilje, Thomas H., Long, Yun O., McNeill, Matthew, Chen, Bei, Lu, Wenshuo, Anumolu, Jaganmohan, Badiger, Sangamesh, Bursulaya, Badry, DiDonato, Michael, Fong, Rina, Ju

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 3.31 MB

english, 2016

17

Development of a virtual reality platform for effective communication of structural data in drug discovery

Kingsley, Laura J., Brunet, Vincent, Lelais, Gerald, McCloskey, Steve, Milliken, Kelly, Leija, Edgardo, Fuhs, Stephen R., Wang, Kai, Zhou, Edward, Spraggon, Glen

Journal:

Journal of Molecular Graphics and Modelling

Year:

2019

File:

PDF, 10.94 MB

2019

18

Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling

McAllister, Christopher S., Ansaldi, Dan, Growcott, Ellena J., Zhong, Yang, Quackenbush, Doug, Wolff, Karen C., Chen, Zhong, Tanaseichuk, Olga, Lelais, Gerald, Barnes, S. Whitney, Federe, Glenn C., Lu

Journal:

Year:

2019

Language:

english

File:

PDF, 1.61 MB

english, 2019

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